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AG Bacterial Physiology
Home
Publications
2022
[1 publication]
M. Halte, M. E. Wörmann, M. Bogisch,
M. Erhardt
, N. Tschowri. BldD-based bimolecular fluorescence complementation for in vivo detection of the second messenger cyclic di-GMP.
Molecular Microbiology
(2022) 10.1111/mmi.14805
2021
[5 publications]
A. Guse, M. Halte, S. Hüsing,
M. Erhardt
. Hook-basal body assembly state dictates sub- strate specificity of the flagellar type-III secretion system.
Molecular Microbiology
(2021) 10.1111/mmi.14805
S. Hüsing, M. Halte, U. van Look, A. Guse, E. J. C. Gálvez, E. Charpentier, D. F. Blair,
M. Erhardt
, T. T. Renault. Control of membrane barrier during bacterial type-III protein secretion.
Nature Communications
(2021) vol. 12, 3999
H. Hu, M. Santiveri, N. Wadhwa, H. C. Berg,
M. Erhardt
, N.M.I. Taylor. Structural basis of torque generation in the bi-directional bacterial flagellar motor.
Trends in Biochemical Sciences
(2021) S0968-0004(21)00139
P. F. Popp,
M. Erhardt
. With or without you: crosstalk between cell division and flagellum assembly.
Developmental Cell
(2021) vol. 56 10.1016/j.devcel.2021.02.013
M. Halte,
M. Erhardt
. Protein Export via the Type III Secretion System of the Bacterial Flagellum.
Biomolecules
(2021) vol. 11 (2), 186
2020
[5 publications]
M. Santiveri, A. Roa-Eguiara, C. Kühne, N. Wadhwa, H. C. Berg,
M. Erhardt
, N. M. I. Taylor. Structure and function of stator units of the bacterial flagellar motor.
Cell
(2020) vol. 183, 244-257.e16
H. Cazzola, L. Lemaire, S. Acket, E. Prost, L. Duma,
M. Erhardt
, P. Čechová, P. Trouillas, F. Mohareb, C. Rossi, Y. Rossez. The impact of plasma membrane lipid composition on flagella-mediated adhesion of enterohemorrhagic Escherichia coli.
mSphere
(2020) vol 5, e00702-20
J. A. Horstmann, M. Lunelli, H. Cazzola, J. Heidemann, C. Kühne, P. Steffen, S. Szefs, C. Rossi, R. K. Lokareddy, C. Wang, L. Lemaire, K. T. Hughes, C. Uetrecht, H. Schlüter, G. A. Grassl, T. E. B. Stradal, Y. Rossez, M. Kolbe,
M. Erhardt
‡. Methylation of Salmonella Typhimurium flagella promotes bacterial adhesion and host cell invasion.
Nature Communications
(2020) vol. 11, 2013
C. Kühne, A. Guse, S. Hüsing,
M. Erhardt
‡. Bacterial Flagella.
eLS
John Wiley & Sons Ltd, Chichester (2020) 10.1002/9780470015902.a0000301.pub3
S. Felgner, I. Spöring, V. Pawar, D. Kocijancic, M. Preusse, C. Falk, M. Rhode, S. Häussler, S. Weiss,
M. Erhardt
. The immunogenic potential of bacterial flagella for Salmonella-mediated tumor therapy.
International Journal of Cancer
(2020) 10.1002/ijc.32807
2019
[3 publications]
S. Nakamura, Y. Hanaizumi, Y.V. Morimoto, Y. Inoue,
M. Erhardt
, T. Minamino, K. Namba. Direct observation of speed fluctuations of flagellar motor rotation at extremely low load close to zero. Molecular Microbiology (2019) vol. 113, 755-765
I. Bernal, J. Börnicke, J. Heidemann, D. Svergun, J. A. Horstmann,
M. Erhardt
, A. Tuukkanen, C. Uetrecht, M. Kolbe. Molecular organization of soluble type III secretion system sorting platform complexes.
Journal of Molecular Biology
(2019) vol. 431, 3787-803
T. T. Renault, A. Guse,
M. Erhardt
‡. Export Mechanisms and Energy Transduction in Type-III Secretion Machines.
Current Topics in Microbiology and Immunology
(2019)
2018
[6 publications]
I. Spöring∗, V. A. Martinez∗, C. Hotz∗, J. Schwarz-Linek∗, K. L. Grady, J. M. Nava-Sedeno, T. Vissers, H. M. Singer, M. Rhode, C. Bourquin, H. Hatzikirou, W. C. Poon, Y. Dufour,
M. Erhardt
‡. Hook length of the bacterial flagellum is optimized for maximal stability of the flagellar bundle.
PLOS Biology
(2018) vol. 16 (9) e2006989
M. Dongre, B. Singh, K. M. Aung, P. Larsson, R. Miftakhova, K. Persson, F. Askarian, M. Johannessen, J. von Hofsten, J. L. Persson,
M. Erhardt
, S. Tuck, B. E. Uhlin, S. N. Wai. Flagella-mediated secretion of a novel Vibrio cholerae cytotoxin affecting both vertebrate and invertebrate hosts.
Communications Biology
(2018) vol. 1 (59)
M. Erhardt
‡. A tale of a tail – eine kurze Geschichte der Biosynthese von Flagellen.
BIOspektrum
(2018) vol. 3, 246-9
I. Spöring*, S. Felgner*, M. Preuße, D. Eckweiler, M. Rhode, S. Häussler, S. Weiss,
M. Erhardt
‡. Regulation of Flagellum Biosynthesis in Response to Cell Envelope Stress in
Salmonella enterica
Serovar Typhimurium.
mBio
(2018) vol. 9 (3) e00736-17
E. Ward, T. T. Renault, E. A. Kim,
M. Erhardt
, K. T. Hughes, D. F. Blair. Type-III Secretion Pore Formed by Flagellar Protein FliP.
Molecular Microbiology
(2018) vol. 107 (1) 94–103
S. Felgner∗, D. Kocijancic∗, M. Frahm, U. Heise, K. Zimmermann,
M. Erhardt
, S. Weiss. Engineered
Salmonella enterica
serovar Typhimurium overcome limitations of anti-bacterial immunity in bacteria-mediated tumor therapy.
OncoImmunology
(2018) vol. 7 (2) e1382791
2017
[11 publications]
F. D. Fabiani∗, T. T. Renault∗, B. Peters, T. Dietsche, E. J. C. Galvez, A. Guse, K. Freier, E. Charpentier, T. Strowig, M. Franz-Wachtel, B. Macek, S. Wagner, M. Hensel,
M. Erhardt
‡. A flagellum-specific chaperone facilitates assembly of the core type-III export apparatus of the bacterial flagellum.
PLOS Biology
(2017) vol. 15 (8) e2002267
S. Thiemann, N. Smit, T. Schauer, U. Roy, E. J.C. Gàlvez, J. Helmecke, T. Robin Lesker, M. Basic, A. Bleich, A. D. Goodmann, U. Kalinke, R. A. Flavell,
M. Erhardt
, T. Strowig. Enhancement of IFNγ production in CD4+ T cells by distinct commensals ameliorates
Salmonella
induced disease.
Cell Host & Microbe
(2017) 10.1016/j.chom.2017.05.005
T. T. Renault, A. O. Abraham, T. Bergmiller, G. Paradis, S. Rainville, E. Charpentier, C. C. Guet, Y. Tu, K. Namba, J. P. Keener, T. Minamino,
M. Erhardt
‡. Bacterial flagella grow through an injection-diffusion mechanism.
eLife
(2017) 10.7554/eLife.23136
D. Kocijancic∗, S. Felgner∗, T. Schauer, M. Frahm, U. Heise, K. Zimmermann,
M. Erhardt
, S. Weiss. Local application of bacteria improves safety of
Salmonella
-mediated tumor therapy and retains advantages of systemic infection.
Oncotarget
(2017) 10.18632/oncotarget.18392
G. Paradis∗, F. F. V. Chevance∗, W. Liou, T. T. Renault, K. T. Hughes, S. Rainville,
M. Erhardt
‡. Variability in bacterial flagella re-growth patterns after breakage.
Scientific Reports
(2017) 10.1038/s41598-017-01302-5
J. Horstmann, E. Zschieschang, T. Truschel, J. de Diego, M. Lunelli, M. Rohde, T. May, T. Strowig, T. Stradal, M. Kolbe,
M. Erhardt
‡. Flagellin phase-dependent swimming on epithelial cell surfaces contributes to productive
Salmonella
gut colonization.
Cellular Microbiology
(2017) 10.1111/cmi.12739
M. Erhardt
, P. Wheatley, E. A. Kim, T. Hirano, Y. Zhang, M. K. Sarkar, K. T. Hughes, D. F. Blair. Mechanism of type-III protein secretion: Regulation of FlhA conformation by a functionally critical charged-residue cluster.
Molecular Microbiology
(2017) 10.1111/mmi.13623
A. Adela Miranda-CasoLuengo, S. C. Kary,
M. Erhardt
, C. Kröger. Small RNA, big effect: control of flagellin production.
Trends in Microbiology
(2017) S0966-842X(17)30230-5
S. Felgner, V. Pawar, D. Kocijancic,
M. Erhardt
, S. Weiss. Tumour-targeting bacteria-based cancer therapies for increased specificity and improved outcome.
Microbial Biotechnology
(2017) vol. 10 1074–1078
M. Erhardt
‡. Energy requirements for protein secretion via the flagellar type-III secretion system.
Methods in Molecular Biology – Bacterial Protein Secretion Systems
(2017) vol. 1615 449–457
M. Erhardt
‡. Fluorescent microscopy techniques to study hook length control and flagella for- mation.
Methods in Molecular Biology – The Bacterial Flagellum: Methods and Protocols
(2017) vol. 1593 37–46
2016
[5 publications]
S. Felgner, M. Frahm, D. Kocijancic, M. Rohde, D. Eckweiler, A. Bielecka, E. Bueno, F. Cava, W.-R. Abraham, R. Curtiss III, S. Häussler,
M. Erhardt
‡, S. Weiss. AroA deficient
Salmonella
Typhimurium is more than a metabolically attenuated mutant.
mBio
(2016) vol. 7 (5) e01220–16
B. Barlag, O. Beutel, D. Janning, F. Czarniak, C. P. Richter, R. Kurre, F. Fabiani,
M. Erhardt
, J. Piehler, M. Hensel. Single molecule super-resolution imaging of proteins in living
Salmonella enterica
using self-labeling enzymes.
Scientific Reports
(2016) vol. 6 p.31601
C. Kühne, H.M. Singer, E. Grabisch, L. Codutti, T. Carlomagno, A. Scrima,
M. Erhardt
‡. RflM mediates target specificity of the RcsCDB phosphorelay system for transcriptional repression of flagellar synthesis in
Salmonella enterica
.
Molecular Microbiology
(2016) vol. 101 (5) 841–55
S. Felgner, D. Kocijancic, M. Frahm, R. Curtiss III,
M. Erhardt
, S. Weiss. Optimizing
Salmonella enterica
Serovar Typhimurium for Bacteria-mediated Tumor Therapy.
Gut Microbes
(2016) vol. 7 (2) 177–77
M. Erhardt
‡. Strategies to block bacterial pathogenesis by interference with motility and chemotaxis.
Current Topics in Microbiology and Immunology
(2016) vol. 398 185–205
2015
[4 publications]
J. A. Deditius, S. Felgner, I. Spöring, C. Kühne, M. Frahm, M. Rohde, S. Weiss,
M. Erhardt
‡. Characterization of novel factors involved in swimming and swarming motility in
Salmonella enterica
serovar Typhimurium.
PLOS ONE
(2015) vol. 10 (8) e0135351
M. Frahm, S. Felgner, D. Kocijancic, M. Rohde, M. Hensel, R. Curtiss III,
M. Erhardt
, S. Weiss. Efficiency of conditionally attenuated
Salmonella
Typhimurium in bacteria mediated tumour therapy.
mBio
(2015) vol. 6 (2) e00254–15
R. W. Hendrix, C.-C. Ko, D. Jacobs-Sera, G. F. Hatfull, A. M. Kropinski, J. M. Denyes,
M. Erhardt
, K. T. Hughes, S. R. Casjens. The genome sequence of
Salmonella
phage Chi.
Genome Announcements
(2015) vol. 3 (1) e01229–14
M. Erhardt
and P. Dersch. Regulatory principles governing
Salmonella
and
Yersinia
virulence.
Frontiers in Microbiology Review
(2015) vol. 6 no. 00949
2014
[4 publications]
M. Erhardt
‡, M. E. Mertens, F. D. Fabiani, K. T. Hughes. ATPase-independent type-III protein secretion in
Salmonella enterica
.
PLOS Genetics
(2014) vol. 10 (11) e1004800
H. M. Singer,
M. Erhardt
‡, K. T. Hughes. Comparative analysis of the secretion capability of early and late flagellar type III secretion substrates.
Molecular Microbiology
(2014) vol. 93, 505–20
H. M. Singer, C. Kühne, J. A. Deditius, K. T. Hughes,
M. Erhardt
‡. The
Salmonella
Spi1 virulence regulatory protein HilD directly activates transcription of the flagellar master operon flhDC.
Journal of Bacteriology
(2014) vol. 196, 1448–57
H. M. Singer and
M. Erhardt
‡. Regulation, Aufbau und Funktion einer bakteriellen Nanomaschine.
BIOspektrum
(2014) vol. 5, 500-2
2006 - 2013
[13 publications]
H. M. Singer,
M. Erhardt
, K. T. Hughes. RflM functions as a transcriptional repressor in the autogenous control of the
Salmonella
Flagellar master operon
flhDC
.
Journal of Bacteriology
(2013) vol. 195, 4274–82
H. M. Singer,
M. Erhardt
, A. M. Steiner, M.-M. Zhang, D. Yoshikami, G. Bulaj, B. M. Olivera, K. T. Hughes. Selective purification of recombinant neuroactive peptides using the flagellar type III secretion system.
mBio
(2012) vol. 29 (3) e00115–12
A. Takaya,
M. Erhardt
, K. Karata, K. Winterberg, T. Yamamoto, K. T. Hughes. YdiV: a dual function protein that targets FlhDC for ClpXP-dependent degradation by promoting release of DNA-bound FlhDC complex.
Molecular Microbiology
(2012) vol. 83 (6) 1268–84
M. Erhardt
‡. Biosynthese des bakteriellen Flagellums – in vivo Längenmessung im Nanomaßstab.
BIOspektrum
(2012) vol. 6 p.679
M. Erhardt
‡, H. M. Singer, D. H. Wee, J. P. Keener, K. T. Hughes. An infrequent molecular ruler controls flagellar hook length in
Salmonella enterica
.
The EMBO Journal
(2011) vol. 30 2948–61
K. T. Hughes,
M. Erhardt
‡. Bacterial Flagella.
eLS
John Wiley and Sons Ltd, Chichester (2011) 10.1002/9780470015902.a0000301.pub2
M. Erhardt
∗, T. Hirano∗, Y. Su, K. Paul, D. H. Wee, S. Mizuno, S.-I. Aizawa, K. T. Hughes. The role of the FliK molecular ruler in hook-length control in
Salmonella enterica
.
Molecular Microbiology
(2010) vol. 75 (5) 1272–84
M. Erhardt
‡, K. T. Hughes. C-ring requirement in flagellar type III secretion is bypassed by FlhDC upregulation.
Molecular Microbiology
(2010) vol. 75 (2) 376–93
A. Koplin, S. Preissler, Y. Ilina, M. Koch, A. Scior,
M. Erhardt
, E. Deuerling. A dual function for chaperones SSB-RAC and the NAC nascent polypeptide-associated complex on ribosomes.
Journal of Cell Biology
(2010) vol. 189 (1) 57–68
M. Erhardt
, R. D. Wegrzyn, E. Deuerling. Extra N-Terminal Residues Have a Profound Effect on the Aggregation Properties of the Potential Yeast Prion Protein Mca1.
PLOS ONE
(2010) vol. 5 (3) e9929 EP
M. Erhardt
, K. Namba, K. T. Hughes. Bacterial Nanomachines: The Flagellum and Type III Injectisome.
Cold Spring Harbor Perspectives in Biology
(2010) vol. 2 (11) a000299
K. Paul∗,
M. Erhardt
∗, T. Hirano, D. F. Blair, K. T. Hughes. Energy source of flagellar type III secretion.
Nature
(2008) vol. 451 (7177) 489–92
F. F. V. Chevance,
M. Erhardt
, C. Lengsfeld, S.-J. Lee, W. Boos. Mlc of
Thermus thermophilus
: a Glucose-Specific Regulator for a Glucose/Mannose ABC Transporter in the Absence of the Phosphotransferase System.
Journal of Bacteriology
(2006) vol. 188 (18) 6561–71